منابع مشابه
Cancer stem cells and self-renewal.
The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered considerable attention over the past several years since Dick and colleagues published a seminal report showing that a hierarchy exists among leukemic cells. In more recent years, a similar hierarchical organization, at the apex of which exists the CSC, has been identified in a variety of solid tumors. Human CSCs a...
متن کاملSelf-Renewal of Stem Cells
Asymmetric division is one of the most fundamental characteristics of adult stem cells , which ensures one daughter cell maintains stem cell status and the other daughter cell becomes committed to differentiation. New data emerged recently that allow us to conclude that asymmetric division has another important aspect: it enables self-maintenance of stem cells.
متن کاملSelf-renewal molecular mechanisms of colorectal cancer stem cells
Colorectal cancer stem cells (CCSCs) represent a small fraction of the colorectal cancer cell population that possess self-renewal and multi-lineage differentiation potential and drive tumorigenicity. Self-renewal is essential for the malignant biological behaviors of colorectal cancer stem cells. While the self-renewal molecular mechanisms of colorectal cancer stem cells are not yet fully unde...
متن کاملHighlight: self-renewal signaling in stem cells.
A number of ground-breaking studies recently identified sets of nuclear factors that together have the unique ability to ‘reset’ an adult differentiated cell type and to ‘erase’ all previous fate decisions and the transcriptional programs that determine phenotype and function of a differentiated cell (Takahashi et al., 2007; Wernig et al., 2007; Yu et al., 2007). As a result, ‘reprogrammed’ cel...
متن کاملEpithelial Stem Cells, Self-renewal and Differentiation in the Intestine
The inner lining of the gut is a simple epithelium that completely selfrenews every five days because of the high mechanical and chemical stress. At the basis of the epithelial homeostasis are intestinal stem cells that are located at the bottom of crypts. Progeny is generated on a daily basis to compensate for the loss of differentiated cells that cover the villi. Under normal conditions, acti...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2010
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-09-2824